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  1. General Info
  2. Effects Info
  3. Reference
Drug Interaction Details
01. General Information
Pair Name Amentoflavone, Cisplatin
Phytochemical Name Amentoflavone (PubChem CID: 5281600 )
Anticancer drug Name Cisplatin (PubChem CID: 5702198 )
Structure of
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Structure of
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02. Combinatorial Therapeutic Effect(s)
Synergistic Effect
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Enhancing Drug Efficacy
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Combination Pair ID: 94
Ref_1
Pair Name Amentoflavone, Cisplatin
Disease Info [ICD-11: 2B66.0] Oral squamous cell carcinoma Investigative
Biological Phenomena Induction-->Apoptosis
Gene Regulation Up-regulation Expression BAK1 hsa578
Up-regulation Expression BAX hsa581
Up-regulation Cleavage CASP3 hsa836
Up-regulation Cleavage CASP9 hsa842
Down-regulation Activity NFKB1 hsa4790
Down-regulation Activity RELA hsa5970
In Vitro Model SAS Tongue squamous cell carcinoma Homo sapiens (Human) CVCL_1675
Result Inactivation of NF-κB and induction of apoptosis through intrinsic caspase-dependent and independent apoptotic pathways are associated with amentoflavone enhanced anti-OSCC efficacy of cisplatin.
03. Reference
No. Title Href
1 Anticancer Efficacy and Mechanism of Amentoflavone for Sensitizing Oral Squamous Cell Carcinoma to Cisplatin. Anticancer Res. 2020 Dec;40(12):6723-6732. doi: 10.21873/anticanres.14695. Click
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